NMEA 0183 data is often wrongly detected by Microsoft’s old “USB plug and play” detection software as a serial mouse. Here is an article I wrote on this back in 2014….still present in Windows 11 !!!

https://digitalyacht.net/2014/04/16/help-my-mouse-has-gone-crazy/

With an iKonvert USB it is pretty easy….just unplug the NMEA 2000 connection (not USB) when it happens and then go in and disable the Serial Mouse in the Device Manager.